Dosage Guidelines. A simplified dosage chart for non-doctors is available here. This independent site has been set up to distribute dosage guidelines for the use of misoprostol in obstetrics and gynaecology. The termination of second-trimester pregnancies requires lower doses of misoprostol because the uterus is, at this point of pregnancy, more sensitive to the drug. Overdoses at this stage of pregnancy are dangerous. Wait three hours before taking another dose. Misoprostol, sold under the brandname Cytotec among others, is a medication used to prevent and treat stomach ulcers, start labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. Most of the time, misoprostol is not for use in women who are able to get pregnant. However, there may be times when it is used in these women. Talk with the doctor. However, there may be times when it is used in these women. Misoprostol is a synthetic prostaglandin E 1 analogue that is used off-label for a variety of indications in the practice of obstetrics and gynecology, including medication abortion, medical management of miscarriage, induction of labor, cervical ripening before surgical procedures, and the treatment of postpartum hemorrhage. Government says home use of misoprostol will be legalised by end of 2018 Misoprostol must be taken regularly to be effective. Women should not take their first dose until the second or third day of their menstrual period (to be sure that they are not pregnant). Do not stop taking misoprostol without talking to your doctor. Abortion with Mifepristone and Misoprostol Before starting. Remember this information is useful for abortion with pills in pregnancies that are 10 weeks or less counted from the first day of your menstrual period. 1. Fetal Diagn Ther. 2004 May-Jun;19(3):266-70. Second and third medical termination of pregnancy with misoprostol without mifepristone. Langer BR(1), Peter C, Firtion C, David E, Haberstich R. Find patient medical information for Misoprostol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.